| 2015-04-25 16:00:19April 25, 2015 | Genesee Community College  | 1 - 3 |  FC Buffalo |
| 2015-05-16 19:00:50May 16, 2015 | FC Buffalo | 2 - 1 |  Cincinnati Saints |
| 2015-05-23 19:00:49May 23, 2015 | FC Buffalo | 1 - 1 |  Detroit City FC |
| 2015-05-29 19:05:15May 29, 2015 | FC Indiana  | 2 - 2 | FC Buffalo |
| 2015-05-31 14:00:05May 31, 2015 | Indiana Fire  | 2 - 2 | FC Buffalo |
| 2015-06-07 13:00:58June 7, 2015 | FC Buffalo | 0 - 2 |  Erie Commodores FC |
| 2015-06-10 18:00:51June 10, 2015 | Greater Binghamton FC  | 1 - 1 | FC Buffalo |
| 2015-06-11 10:00:18June 11, 2015 | Rochester Rhinos  | 3 - 0 | FC Buffalo |
| 2015-06-13 19:30:38June 13, 2015 | Michigan Stars FC  | 1 - 3 | FC Buffalo |
| 2015-06-21 13:00:23June 21, 2015 | FC Buffalo | 2 - 0 |  Fort Pitt Regiment |
| 2015-06-27 19:00:16June 27, 2015 | AFC Cleveland  | 1 - 1 | FC Buffalo |
| 2015-07-03 19:00:00July 3, 2015 | Erie Commodores FC | 2 - 4 | FC Buffalo |
| 2015-07-05 13:00:32July 5, 2015 | FC Buffalo | 1 - 0 | Greater Binghamton FC |
| 2015-07-10 19:00:08July 10, 2015 | FC Buffalo | 3 - 0 |  Lansing United |
| 2015-07-12 16:00:58July 12, 2015 | Fort Pitt Regiment | 1 - 2 | FC Buffalo |
| 2015-07-17 19:00:07July 17, 2015 | FC Buffalo | 2 - 3 | AFC Cleveland |
Madison 56ers
AFC Cleveland
Detroit City FC
Indiana Fire
FC Buffalo
Lansing United
Erie Commodores FC
Minnesota United Reserves
Michigan Stars FC
Cincinnati Saints
FC Indiana
Fort Pitt Regiment
Minnesota TwinStars
